Advances in Superparamagnetic-Synthetic Affinity Ligand Functionalised Nanomaterials for Biomagnetic

  • Magnostics
  • Publications
  • May 06, 2021

Title: Advances in Superparamagnetic-Synthetic Affinity Ligand Functionalised Nanomaterials for Biomagnetic Separation
Author: Conor Fields, Peng Li, James J. O’Mahony, and Gil Lee
Subjects: Biomagnetic Separation; Nanomaterials
Is Part Of:
[Peer Reviewed Manuscript]
Description: The downstream processing of proteins remains the largest cost in protein production, and is largely attributed to rigorous chromatographic purification protocols, where the stringency of purity for biopharmaceutical products sometimes exceeds 99%. With an ever burgeoning biotechnology market, there is a constant demand for alternative purification methodologies, to ameliorate the dependence on chromatography, while still adhering to regulatory concerns over product purity and safety. In this article, we present an up-to-date view of bioseparation, with emphasis on magnetic separation and its potential application in the field. Additionally, we discuss the economic and performance benefits of synthetic ligands, in the form of peptides and miniaturized antibody fragments, compared to full-length antibodies. We propose that adoption of synthetic affinity ligands coupled with magnetic adsorbents, will play an important role in enabling sustainable bioprocessing in the future.

/images/uploads/magnostics/publications/DSP.jpg

Download Full Article: Advances in Affinity Ligand-Functionalized Nanomaterials for Biomagnetic Separation

C Fields, P Li, JJ O'Mahony, GU Lee
Biotechnology and bioengineering 113 (1), 11-25